Compile Data Set for Download or QSAR
maximum 50k data
Found 361 of ec50 for POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
having polymerids = 50000444,50000606,50003158 and
complexids = 50000164,50001629
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442471(CHEMBL2440363)
Affinity DataEC50:  0.900nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442470(CHEMBL401942)
Affinity DataEC50:  2.40nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557812(US11365181, Compound 03058)
Affinity DataEC50:  8nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410081(CHEMBL361184)
Affinity DataEC50:  10nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420073(CHEMBL2047506)
Affinity DataEC50:  10nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410081(CHEMBL361184)
Affinity DataEC50:  10nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50592356(CHEMBL4458793)
Affinity DataEC50:  18nMAssay Description:Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410077(CHEMBL180886)
Affinity DataEC50:  20nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50410077(CHEMBL180886)
Affinity DataEC50:  20nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465779(CHEMBL4278049)
Affinity DataEC50:  20nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463349(CHEMBL4250878)
Affinity DataEC50:  20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463341(CHEMBL4238783)
Affinity DataEC50:  20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415511(CHEMBL598553)
Affinity DataEC50:  21nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557809(US11365181, Compound 03043)
Affinity DataEC50:  23nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415531(CHEMBL592297)
Affinity DataEC50:  23nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50121052(CHEMBL3621438)
Affinity DataEC50:  24nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415509(CHEMBL599164)
Affinity DataEC50:  25nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415502(CHEMBL598126)
Affinity DataEC50:  27nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415516(CHEMBL599374)
Affinity DataEC50:  28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415507(CHEMBL604937)
Affinity DataEC50:  28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415529(CHEMBL589898)
Affinity DataEC50:  29nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463346(CHEMBL4250403)
Affinity DataEC50:  30nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420077(CHEMBL2047511)
Affinity DataEC50:  30nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463345(CHEMBL4247074)
Affinity DataEC50:  34nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Rattus norvegicus)
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50601513(CHEMBL5180351)
Affinity DataEC50:  37nMAssay Description:Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataEC50:  37nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50254401(CHEMBL4093377)
Affinity DataEC50:  37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50120996(CHEMBL3621449)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465781(CHEMBL4276984)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465775(CHEMBL1703636)
Affinity DataEC50:  40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50463342(CHEMBL4247002)
Affinity DataEC50:  40nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415526(CHEMBL591302)
Affinity DataEC50:  44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415521(CHEMBL609624)
Affinity DataEC50:  44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415520(CHEMBL599376)
Affinity DataEC50:  49nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557815(US11365181, Compound 03066)
Affinity DataEC50:  49nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50513737(CHEMBL4549421)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM50592357(CHEMBL5185685)
Affinity DataEC50:  50nMAssay Description:Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465773(CHEMBL4277250)
Affinity DataEC50:  50nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50121053(CHEMBL3621439)
Affinity DataEC50:  50nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50513734(CHEMBL4516269)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415506(CHEMBL599781)
Affinity DataEC50:  53nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM557810(US11365181, Compound 03044)
Affinity DataEC50:  57nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50143560((E)-N-[(S)-1-(4-Cyclopropylmethyl-3,4-dihydro-2H-b...)
Affinity DataEC50:  60nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50143560((E)-N-[(S)-1-(4-Cyclopropylmethyl-3,4-dihydro-2H-b...)
Affinity DataEC50:  60nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50143560((E)-N-[(S)-1-(4-Cyclopropylmethyl-3,4-dihydro-2H-b...)
Affinity DataEC50:  60nMAssay Description:Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339281(5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(...)
Affinity DataEC50:  60nMAssay Description:Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50595542(CHEMBL5204124)
Affinity DataEC50:  60nMAssay Description:Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell pat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50415517(CHEMBL599375)
Affinity DataEC50:  62nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50121054(CHEMBL3621440)
Affinity DataEC50:  62nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50121055(CHEMBL3621441)
Affinity DataEC50:  64nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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