Found 361 of ec50 for POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2
having polymerids = 50000444,50000606,50003158 and
complexids = 50000164,50001629
having polymerids = 50000444,50000606,50003158 and
complexids = 50000164,50001629
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 0.900nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 2.40nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 8nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 10nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFPMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 20nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 21nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 23nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 23nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 24nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 25nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 27nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 28nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 29nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 30nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 34nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Rattus norvegicus)
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Shanghai Institute Of Materia Medica
Curated by ChEMBL
Affinity DataEC50: 37nMAssay Description:Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 37nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 37nMAssay Description:Activation of KCNQ2/3 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 40nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 44nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 49nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 49nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 50nMAssay Description:Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Activation of human Kv7.2/7.3 by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 53nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma
US Patent
Shanghai Zhimeng Biopharma
US Patent
Affinity DataEC50: 57nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Effect on outward potassium currents in whole-cell patchclamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Mus musculus)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell pat...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 62nMAssay Description:Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 62nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 64nMAssay Description:Activation of human Kv7.2/7.3 expressed in CHOK1 cellsMore data for this Ligand-Target Pair